target ㅡ

The TLR (Toll-like receptor) is one of the major factors in the pathogenesis of autoimmune diseases. TLR signaling pathway plays a crucial role in the activation of innate immune responses, which is the first line of defense against external/foreign substances. TLR immediately responds to the invading pathogenic substances and secretes various cytokines to help the development of acquired immunity. However, if TLR signaling is over-activated, it can cause autoimmune or inflammatory diseases such as systemic lupus erythematosus, psoriasis or rheumatoid arthritis, which can be treated by directly blocking the signal transduction of the TLR.

Semin Cancer Biol. 64:61 (2020). doi: 10.1016/j.semcancer.2019.05.002